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Title
Biogen advances disease therapies through cloud-based AI on Databricks
…a Demo Login Contact Us Try Databricks Customer Stories / Biogen CUSTOMER STORY Advancing disease therapies through cloud-based AI 2 million Genomic variants analyzed in 15 minutes 2 drug targets Discovered for…
Description
Biogen migrated its on-premises genomics data infrastructure to Databricks for Genomics on AWS, using the UK Biobank's 500,000-participant dataset and machine learning models to identify genetic variants linked to human longevity and neurological disease, discovering two new drug targets for neurodegenerative diseases like Alzheimer's and Parkinson's.
…variants that impact human longevity and neurological status. These discoveries led to the identification of two new drug targets and unearthed insights into neurodegenerative diseases like Alzheimer’s and Parkinson’s. Accelerating the discovery of new disease treatments and therapies “What’s real…
Company
Biogen
…rity and Trust Ready to get started? Get a Demo Login Contact Us Try Databricks Customer Stories / Biogen CUSTOMER STORY Advancing disease therapies through cloud-based AI 2 million Gen…
Problem
Insufficient storage capacity in Biogen's existing data center made collecting and analyzing genomics data at scale impossible, and their network bandwidth couldn't handle transferring so much information; in 2018 these issues led to a one-week outage of Biogen's high-performance compute cluster.
…nk’s 500,000 volunteer participants, Biogen faced major informatics challenges. Insufficient storage capacity in their existing data center made collecting and analyzing data at scale impossible. Their network bandwidth couldn’t handle transferring so much information and, i…
Solution
Biogen collaborated with DNAnexus and Databricks to migrate its on-premises data infrastructure into the AWS cloud using Databricks for Genomics, and with Delta Lake took a pipeline that previously required 2 weeks to process 700,000 variants and optimized it to annotate 2 million variants in approximately 15 minutes.
…ource technologies to accelerate the ingestion and analysis of large data sets. Collaborating with DNAnexus and Databricks, Biogen migrated their on-premises data infrastructure into the Amazon Web Services (AWS) cloud. These combined efforts simplified operations and helped reduce average data pro…
…forts simplified operations and helped reduce average data processing time. And with Delta Lake, Biogen took a pipeline that previously required 2 weeks to process 700,000 variants, and optimized it to annotate 2 million variants in approximately 15 minutes. “The UK Biobank data set is challenging because of its sheer size and complexi…
Business value
By combining the DNAnexus platform with Databricks for Genomics, Biogen was able to use UK Biobank data to identify genes containing protein-truncating variants that impact human longevity and neurological status, leading to the identification of two new drug targets and insights into neurodegenerative diseases like Alzheimer's and Parkinson's.
…s, Biogen could focus on data science productivity and targeting new therapies. By combining the DNAnexus platform with Databricks for Genomics, Biogen was able to use UK Biobank data to identify genes containing protein-truncating variants that impact human longevity and neurological status. These discoveries led to the identification of two new drug targets and unearth…
Headline outcome
…forts simplified operations and helped reduce average data processing time. And with Delta Lake, Biogen took a pipeline that previously required 2 weeks to process 700,000 variants, and optimized it to annotate 2 million variants in approximately 15 minutes. “The UK Biobank data set is challenging because of its sheer size and complexi…
Use case type
Analytics augmentation
…ok a pipeline that previously required 2 weeks to process 700,000 variants, and optimized it to annotate 2 million variants in approximately 15 minutes. “The UK Biobank data set is challenging because of its sheer size and complexi…
AI capabilities
Predictive Analytics
…s, all of which have a significant impact on the human lifespan,” said Sexton. “We’ve been able to build out ML models that allow us to understand how genomic variants impact the functionality and the possible success of other drugs we’re developing. With drastically improved data efficiency and discovery, we now have a unique o…
Industry
Life Sciences
…diseases such as Alzheimer's and Parkinson's. Share this post Details Industry : Healthcare and Life Sciences Use Case : Data Science , Data Engineering Cloud : AWS Product : Agent Bricks ,…
Technology
Databricks for Genomics, Delta Lake, AWS
…ic data at petabyte scale.” Simplifying informatics and infrastructure at scale Databricks introduced Databricks for Genomics, a runtime specifically targeted at genomic data workflows, and a component of…
…thcare and Life Sciences Use Case : Data Science , Data Engineering Cloud : AWS Product : Agent Bricks , Delta Lake Ready to get started? Try Databricks for free Learn more about our product Talk…
…and Databricks, Biogen migrated their on-premises data infrastructure into the Amazon Web Services (AWS) cloud. These combined efforts simplified operations and helped reduce average data pr…
Deployment model
cloud
…and Databricks, Biogen migrated their on-premises data infrastructure into the Amazon Web Services (AWS) cloud. These combined efforts simplified operations and helped reduce average data pr…
Deployment options
cloud
…and Databricks, Biogen migrated their on-premises data infrastructure into the Amazon Web Services (AWS) cloud. These combined efforts simplified operations and helped reduce average data pr…
